*The program book on this page will update based on changes to the program during the conference

SESSION 1: FROM DISCOVERY, CLINICAL CHALLENGES TO ELIMINATION

Keynote lecture: From yellow fever to hepatitis C and back

Charles Rice - Rockefeller University, USA

Keynote lecture: HCV Elimination: Where there’s a will there’s a way

Susanna Naggie - Duke University, USA

Keynote lecture: Hepatitis C elimination: from a Nobel Prize to a Nobel cause

John Ward - Taskforce for Global Health, Coalition for Global Hepatitis Elimination, USA

SESSION 2: Innate immunity and virus-host interaction

Keynote lecture: New insights into flavivirus – host cell interactions: a tale of proteins and lipids

Ralf Bartenschlager - Heidelberg University, Germany

Plenary talk: Calling the shots: micro(RNA)-management of HCV infection

Selena Sagan - McGill University, Canada

ABSTRACT TALKS (1)

A TLR3-based directed evolution approach identifies an HCV NS3 helicase point mutation specifically affecting (-) strand synthesis

Philipp Ralfs - Heidelberg University, Germany

HCV p7-mediated inhibition of signal peptide peptidase (SPP) promotes HCV assembly by facilitating Core localization to the endoplasmic reticulum (ER) and Core-E1 interaction

Ming-Jhan Wu - University of Texas Medical Branch, USA

Identification of phosphorylation sites on viral and host proteins regulating west nile virus replication

Holly Ramage - Thomas Jefferson University, USA

Mutations in the interferon sensitivity determining region dramatically increase hepatitis C virus replication leading to direct viral pathogenesis

Paul Rothhaar - Heidelberg University, Germany

How a virus builds a house: host factors required for flavivirus replication organelle formation

Jonathan Owen - Emory University, USA

5-MINUTE PITCH TALKS (1)

Identification of hepatitis E virus restriction factors by utilizing arrayed human and porcine ISG screens

Volker Kinast - Carl Von Ossietzky University, Germany

NS5A oligomerization-dependent membrane remodeling activity correlates with HCV replicative fitness and is a direct and common target of different NS5A inhibitors

Sameh Lofti Abdalla - University of Texas Medical Branch, USA

PLA2G4C induced by HCV infection is involved in the accumulation of lipid droplets via the inhibition of lipolysis

Masahiko Ito - Hamamatsu University School of Medicine, Japan

Elucidating the switch from translation to replication in the HCV life cycle

Manolya Sag - University of British Columbia, Canada

Genetic and molecular characterization of species-specific receptor transport protein 4 (RTP4)-mediated HCV repression

Michael Schwoerer - Princeton University, USA

Regulation of protein kinase R by hepatitis C virus nonstructural protein 5A

Carla Gallardo - Queen’s University, Canada

What do HCV Core and NS5A partners in crime tell us about hepatocyte deregulations? Interacting host factors and enriched pathways identified in an infection system

Angeliki Anna Beka - Institut Pasteur, France

SESSION 3: DEVELOPING NEXT GENERATION VACCINES

Keynote lecture: Defining humoral correlates of protection and risk in Dengue viral infection

Galit Alter - Moderna, USA / Harvard University, USA

Plenary talk: Integrated organ immunity

Bali Pulendran - Stanford University, USA

ABSTRACT TALKS (2)

Design and non-viral delivery of live attenuated virus vaccine to prevent chronic hepacivirus (HCV-like virus) infection

Amit Kapoor - Nationwide Children’s Hospital , USA

Preclinical evaluation of T and B cell targeting DNA/ MVA-based HCV vaccine candidates in mice and rhesus macaques

Rama Amara - Emory University, USA

Supramolecular assembly of Toll-like receptor 7/8 agonist into multimeric virus-mimicking polymer assemblies of E1E2 and core and evaluation of immune responses

Thomas Fuerst - University of Maryland, USA

Structural and biochemical studies of flaviviruses in complex with antibodies and attachment factors

Richard Kuhn - Purdue University, USA

Lipid/mRNA HCV E1E2 vaccines elicit broadly neutralizing antibodies and the requirement of transmembrane domains

Steven Foung - Stanford University, USA

5-MINUTE PITCH TALKS (2)

Extensive C->U transition biases in the genomes of HCV and a wide range of mammalian RNA viruses; hostmediated editing of viral RNA?

Peter Simmonds - University of Oxford, United Kingdom

Rationally designed attenuated HCV variants for vaccine development

Meital Gal-Tanamy - Bar-ilan University, Israel

Bispecific antibodies against hepatitis C virus E1E2 show enhanced breadth and potency in HCV pseudoparticle and authentic virus assays

Laura Radić - Amsterdam University Medical Centers, Netherlands

Optimization of HCV vaccine antigens to enhance binding of broadly neutralizing antibody unmutated ancestors

Desiree Wright - Johns Hopkins Medical Institute, USA

Iterative structure-based design of a hyperstable soluble hepatitis C virus E1E2 heterodimer

Joan Capella-Pujol - Amsterdam University Medical Centers, Netherlands

SESSION 4: FLAVIVIRUS STRUCTURE, FUNCTION AND VIRAL CYCLE

Keynote lecture: Evolution of alphavirus entry

Daved Fremont - Washington University in Saint Louis, USA

Plenary talk: Receptor binding and entry of hepatitis C virus

Joe Marcotigiano - National Institutes of Health, USA

ABSTRACT TALKS (3)

Neutralizing antibodies exploit vulnerable E2 amino acids to mediate repeated, spontaneous HCV clearance

Nicole Frumento - Johns Hopkins University, USA

A new assay for the quantification of HCV E2- or E1- dependent neutralizing antibody responses in polyclonal plasma

Anne Gao - Johns Hopkins University, USA

Dengue virus serotype-specific inhibition of T cell responses is due to a single amino acid polymorphism in the envelope protein

Jack Stapleton - University of Iowa, USA

Understanding the virus-host protein-protein interaction network of the hepatitis E virus

Philip Meuleman - Ghent University, Belgium

IL-15-induced activation of liver damaging bystander CD8+ T cells is counteracted by Ca2+ signals in viral hepatitis

Eui-Cheoi Shin - Korea Advanced Institute of Science and Technology (KAIST), South Korea

A structural perspective into Hepatitis C Virus E1E2 glycoprotiens using a lentvirus-pseudoparticle approach

Shishir Poudyai - Purdue University, USA

Investigating the role of NS2A in the zika virus life cycle

Breana Landry - University of British Columbia, Canada

SESSION 5: REPLICATION SYSTEMS AND ANIMAL MODELS

Keynote lecture: Breaking the species barrier of hepatitis C virus

Alexander Ploss - Princeton University, USA

Plenary talk: Early events in the HCV life cycle

Glenn Randall - University of Chicago, USA

ABSTRACT TALKS (4)

Impact of HBV pre-core mutation and IFNα on hepatocyte proteome in chronically-infected primary human hepatocytes

Lefteris Michailidis - Emory University, USA

Automated high-throughput screen discovers members of the Akt serine/threonine kinase family as targets for treatment of HEV virus infection

Mara Klöhn - Ruhr University Bochum, Germany

Comprehensive epitope mapping and structural studies of antibodies from an HCV elite neutralizer reveal bNAbs that bind multiple antigenic regions on the E2 glycoprotein

Andrew Flyak - Cornell University, USA

The role of B cells and their antibodies in the clearance of an HCV-related rodent hepacivirus

John Gridley Emory University, USA

5-MINUTE PITCH TALKS (3)

Phenotype and fate of liver resident CD8 T cells during acute and chronic hepacivirus infection

Piyush Dravid - Nationwide Children’s Hospital, USA

HCV-Specific CD4+ T-Cells are targeted by HIV-1 for infection and viral reservoir persistence

Samaa Gobran - Centre De Recherche Du Chum, Canada

Insertions in hepatitis C virus hypervariable region 1 as a novel antibody evasion mechanism

Chrsitina Holmboe Olesen - University of Copenhagen, Denmark

The role of Foxp3+ regulatory T cells in orchestrating antiviral T and B cell responses during an acute Hepacivirus infection

Fengzhi Jin - Emory University, USA

Analysis of intrahepatic CD8+ T cells with different viral epitope-specificity during primary and secondary hepacivirus infection

Jarrett Lopez-Scarim - Albert Einstein College of Medicine, USA

Hepatitis C viral evolution after childbirth bears signatures of both CD8+ T cell and antibody pressure in women with postpartum suppression of viral replication

Chris Phelps - Nationwide Children’s Hospital, USA

SESSION 6: EMERGING AND REEMERGING FLAVIVIRUSES, VECTOR TRANSMISSION AND BIOLOGY

Keynote lecture: Zika virus vaccine development: Experience is not preparedness

Ted Pierson - National Institutes of Health, USA

Plenary talk: Flavivirus-vector interactions

Greg Ebel - Colorado State University, USA

ABSTRACT TALKS (5)

Treating dengue infections in vivo using mRNA encoded Cas13

Chiara Zurla - Emory University, USA

Genetic and functional characterization of the membrane region of the pestiviral NS2 protein

Olaf Isken - University of Luebeck, Germany

A viral footprint provides clues on how dengue virus escapes the acid bubble

Jiayu Zhang - Princeton University, USA

Two is better than one: exploring the helicase and capping interfaces between NS3 and NS5 in flavivirus infection

Quinn Abram - McGill University, Canada

UPDATE ON CHIM

Jordan Feld - Toronto Centre for Liver Disease, Canada

Jake Liang - National Institutes of Health, USA

SESSION 7: CORRELATES OF PROTECTIVE IMMUNITY

Keynote lecture: CD8 T cell adaptation to chronic viral infection

Rafi Ahmed - Emory University, USA

Plenary talk: What is a protective CD4+ T cell response against HCV?

Christopher Walker - Nationwide Children’s Hospital, USA

ABSTRACT TALKS (6)

Epigenetic scars in regulatory T cells are retained after successful treatment of chronic hepatitis C with directacting antivirals

So-Young Kim - Korea Advanced Institute Of Science And Technology (KAIST), South Korea

Analysis of circulating and intrahepatic CD4+ T cell response in acute resolving HCV

Heather Blasczyk - Nationwide Children’s Hospital, USA

Memory B cell responses in chronic hepatitis C patients following direct-acting antiviral treatment

Fang Chen - Scripps Research Institute, USA

Activation of CD4 T follicular helper cells correlates with B cell expansion and neutralizing antibodies during HCV reinfection and clearance

Elsa Gomez Escobar - CRCHUM, Canada

ROUND TABLE DISCUSSION

Justin Bailey, Johns Hopkins University, USA